Large-Scale epidemiological research has reported that the appendix might play a role in the development of Parkinson’s disease. Thus, the people who have removed their appendix have a reduced risk to have Parkinson’s disease. The international team of researchers studied two datasets, which involved a large number of people from Sweden. They revealed that the removal of the appendix has a decreased risk of developing Parkinson’s disease. They also discovered that the human appendix comprises of clusters of protein. These clusters are known as alpha-synuclein, these are in a form that is linked with the disease.
Moreover, these major volume proteins are toxic and contribute to the progression of the disease. The fact adds weight to the theory that this destructive neurodegenerative disease may take place in other body parts also. The research included nearly 1.7 million people. There were more than 500,000 people who had undergone an appendectomy. In conclusion, the researchers accepted an evident link between the gut and brain disease. To link the relationship between Parkinson’s and appendix the neuroscientists combined various details. The details were belonging to the Parkinson’s Progression Markers Initiative and the Swedish National Patient Registry. However, the comparison was not a guess depending on very less or no information; there’s an expanding pool of proofs. This suggests that Parkinson’s disease starts below down in the stomach and traverses up to the brain.
Additionally, the early sign of the condition is constipation. There is a possibility for gastrointestinal-tract based therapies that could block the formation and spread of toxic proteins in the body. This could be a preventive and early treatment for Parkinson’s disease said, Prof Viviane Labrie. She belongs to the Center for Neurodegenerative Science at the Van Andel Research Institute in Michigan. John Woulfe, a scientist from the Ottawa Hospital Research Institute’s Neuroscience Program, says the research is essential. It provides some support for the idea that Parkinson disease can develop outside the brain. He said he found the research output convincing.